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KMID : 1144320140460040248
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감염과 화학요법
2014 Volume.46 No. 4 p.248 ~ p.252
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Factors Associated with a Strong Response to the T-SPOT.TB in Patients with Extrapulmonary Tuberculosis
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Lee Yu-Mi
Kim Sun-Mi
Park Su-Jin
Lee Sang-Oh
Choi Sang-Ho
Kim Yang-Soo
Woo Jun-Hee
Kim Sung-Han
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Abstract
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Limited data are available on which factors are associated with strong immunologic responses to T-SPOT.TB. We investigated the factors associated with strong positive responses in patients with extrapulmonary tuberculosis (E-TB). Of 173 patients with E-TB who gave positive results on T-SPOT.TB, 26 (15%) with a strong positive response (defined as ≥1,000 spot-forming units (SFU)/2.5×105 PBMC to ESAT-6 or CFP-10) and 71 (41%) with a low positive response (≤ 99 SFU (6-99 SFU)/2.5×105 PBMC) were further analyzed. Miliary TB was independently associated with a strong positive response to T-SPOT.TB, while advanced age and immunosuppression were independently associated with weak positive T-SPOT.TB responses.
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KEYWORD
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Interferon-gamma release assay, Tuberculosis, Miliary
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